Investigation of the sequence and length dependence for cell-penetrating prenylated peptides.

Autor: Wollack JW; Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455, USA., Zeliadt NA, Ochocki JD, Mullen DG, Barany G, Wattenberg EV, Distefano MD
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jan 01; Vol. 20 (1), pp. 161-3. Date of Electronic Publication: 2009 Nov 13.
DOI: 10.1016/j.bmcl.2009.11.026
Abstrakt: Cell penetrating peptides are useful delivery tools for introducing molecules of interest into cells. A new class of cell penetrating molecules has been recently reported-cell penetrating, prenylated peptides. In this study a series of such peptides was synthesized to examine the relationship between peptide sequence and level of peptide internalization and to probe their mechanism of internalization. This study revealed that prenylated peptides internalize via a non-endocytotic pathway regardless of sequence. Sequence length and identity was found to play a role in peptide uptake but prenylated sequences as short as two amino acids were found to exhibit significant cell penetrating properties.
(Copyright 2009 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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