Mitochondria-targeted antioxidant SkQR1 selectively protects MDR (Pgp 170)-negative cells against oxidative stress.

Autor: Fetisova EK; A N Belozersky Institute of Physico-Chemical Biology and Institute of Mitoengineering, M V Lomonosov Moscow State University, Moscow, Russia., Avetisyan AV, Izyumov DS, Korotetskaya MV, Chernyak BV, Skulachev VP
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 2010 Feb 05; Vol. 584 (3), pp. 562-6. Date of Electronic Publication: 2009 Dec 06.
DOI: 10.1016/j.febslet.2009.12.002
Abstrakt: A conjugate of plastoquinone with decylrhodamine 19 (SkQR1) selectively accumulates in mitochondria of normal and tumor cells. SkQR1 protected the cellular pool of reduced glutathione under oxidative stress. Overexpression of P-glycoprotein (Pgp 170) multidrug resistance pump strongly suppresses accumulation of SkQR1. The inhibitors of Pgp 170 stimulate accumulation of SkQR1 in various cell lines indicating that SkQR1 is a substrate of Pgp 170. The protective effect of SkQR1 against oxidative stress is diminished in the cells overexpressing Pgp 170. It is suggested that mitochondria-targeted antioxidants could selectively protect normal (Pgp 170-negative) cells against the toxic effect of anti-cancer treatments related to oxidative stress.
(2009. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: