| Autor: |
Thrall KD; Battelle, Pacific Northwest Division, Richland, WA 99354-1793, USA. karla.thrall@pnl.gov, Soelberg JJ, Powell T, Corley RA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of long-term effects of medical implants [J Long Term Eff Med Implants] 2008; Vol. 18 (2), pp. 133-44. |
| DOI: |
10.1615/jlongtermeffmedimplants.v18.i2.20 |
| Abstrakt: |
A physiologically based pharmacokinetic model was developed to describe the silicone constituent octamethylcyclotetrasiloxane (D4) and its migration from intact or ruptured silicone gel-filled breast implants into surrounding tissues. D4 is a representative low-molecular weight constituent of silicone gel that is soluble enough in biological fluids to migrate from the implant and into surrounding tissues. The simulations were based on a representative young adult (premenopausal) woman and a mature (postmenopausal) woman using worst-case exposure conditions (i.e., complete rupture of the largest implant available, maximum levels of D4 in silicone, equal solubility of D4 in breast tissue and gel, and a range of breast tissue fat contents). The results indicate that D4 is cleared primarily by exhalation with highest concentrations achieved briefly in breast tissues of a representative postmenopausal woman. Maximum D4 levels in breast tissues for this scenario were estimated to be approximately 750 ppb with over 90% cleared in about 20 days. Thus, it is unlikely that D4 would be detected in any tissue within a few weeks of receiving an implant, even if immediately ruptured, under the assumptions used in this model. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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