Impact of age at diagnosis on prognosis and treatment in laryngeal cancer.

Autor: Reizenstein JA; Department of Oncology, Orebro University Hospital, Orebro, Sweden. johan.reizenstein@orebroll.se, Bergström SN, Holmberg L, Linder A, Ekman S, Blomquist E, Lödén B, Holmqvist M, Hellström K, Nilsson CO, Brattström D, Bergqvist M
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2010 Aug; Vol. 32 (8), pp. 1062-8.
DOI: 10.1002/hed.21292
Abstrakt: Background: The aims of this study were to analyze how age affects treatment and treatment outcome, and to determine whether tumor characteristics differ between different age groups with laryngeal cancer.
Methods: Patients with laryngeal cancer during 1978-2004 in the Uppsala-Orebro region in Sweden were retrospectively studied.
Results: There were no significant differences in the 945 cases between age groups concerning major patient and tumor characteristics, such as male/female ratio, distribution of glottic/supraglottic tumors, stage, or site of recurrence. Overall survival (OS) and disease-specific survival (DSS) were worse among the oldest, although a significant proportion was cured. Relapse risk was lower among the oldest (12%) compared with the youngest (23%). The risk of never becoming tumor-free was 25% among the oldest and 7% in the youngest. Among the most elderly, only 1 late recurrence occurred.
Conclusion: Elderly patients with laryngeal carcinoma cope well with treatment. Undertreatment may determine outcome more than age. The oldest group should be followed for a minimum of 2 years.
(2009 Wiley Periodicals, Inc. Head Neck, 2010.)
Databáze: MEDLINE
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