| Autor: |
Sivakumar G; Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR 72401, USA. sivakumar@libero.it, Vail DR, Nair V, Medina-Bolivar F, Lay JO Jr |
| Jazyk: |
angličtina |
| Zdroj: |
Biotechnology journal [Biotechnol J] 2009 Dec; Vol. 4 (12), pp. 1704-11. |
| DOI: |
10.1002/biot.200900207 |
| Abstrakt: |
Diabetes is one of the nation's most prevalent, debilitating and costly diseases. For diabetes, frequent insulin treatment is very expensive and may increase anti-insulin antibody production, which may cause unwanted side effects. Corosolic acid may also have some efficacy in the treatment of diabetes, but without induction of anti-insulin antibodies. Recently, corosolic acid from Lagerstroemia speciosa L. leaf extracts has been reported to act via an indirect mechanism (unlike insulin) in animal experiments. The insulin-complementary anti-diabetic therapeutic value observed in these Japanese preliminary clinical trials has led to renewed interest in the biosynthesis of this compound. So far, there has been no clear evidence for a corosolic acid biosynthetic pathway in plants. This article provides possible roles of corosolic acid and hypothetical information on the biosynthetic pathway in plants. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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