Stress induced cognitive deficit is differentially modulated in BALB/c and C57Bl/6 mice: correlation with Th1/Th2 balance after stress exposure.

Autor: Palumbo ML; CEFYBO-CONICET, 1(a). Cátedra de Farmacología, Facultad de Medicina, UBA, 1121 Ciudad de Buenos Aires, Argentina., Canzobre MC, Pascuan CG, Ríos H, Wald M, Genaro AM
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2010 Jan 25; Vol. 218 (1-2), pp. 12-20. Date of Electronic Publication: 2009 Nov 26.
DOI: 10.1016/j.jneuroim.2009.11.005
Abstrakt: This work shows a comparative study on the effects of chronic mild stress upon learning and memory and immunity, in BALB/c and C57BL/6 mice. Stressed BALB/c, but not C57Bl/6 mice, showed a poor learning performance, morphological alterations in the hippocampus with an increase in oxidative stress. A correlation between poor memory performance and the increase of the Th2/Th1 balance was found. Our results suggest that vulnerability to cognitive deficit associated with stress exposition could be related to a differential regulation of Th1/Th2 cytokine balance, suggesting a better learning performance for individuals that produce Th1 type cytokine after stress exposition.
(Copyright 2009 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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