| Autor: |
Williams AL; Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise (BRITE), North Carolina Central University, Durham, NC 27707, USA. awilliams@nccu.edu, Dandepally SR, Kotturi SV |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular diversity [Mol Divers] 2010 Nov; Vol. 14 (4), pp. 697-707. Date of Electronic Publication: 2009 Nov 21. |
| DOI: |
10.1007/s11030-009-9208-y |
| Abstrakt: |
The synthesis of 17 phenoxy substituted 4-chloro-N-(aryl/alkyl)thiophene-2-sulfonamides using a PMB protection/deprotection strategy is described. Nucleophilic displacement of p-methoxybenzyl (PMB) protected 4,5-dichloro-N-(aryl/alkyl)-thiophene-2-sulfonamides was carried out with different phenols under mild basic conditions. Reaction times of 3-6 h and overall yields of 78-98% were achieved with the PMB group in place compared to no reaction without this protecting group. The PMB group was easily and selectively removed in 68-98% yield using TFA in DCM. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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