| Autor: |
Byzova NA, Sviridov VV, Gavrilova NF, Raspopova EN, Iakovleva IV, Generalova AN, Lukin IuV, Cherkasova VV, Zherdev AV, Dzantiev BB |
| Jazyk: |
ruština |
| Zdroj: |
Bioorganicheskaia khimiia [Bioorg Khim] 2009 Jul-Aug; Vol. 35 (4), pp. 533-41. |
| DOI: |
10.1134/s1068162009040104 |
| Abstrakt: |
The use of two monoclonal antibody types specific to different epitopes of diphtheria toxin systems have been developed to reveal diphtheria corynebacteria toxigenicity rapidly based on immunochromatographic and latex-agglutination detection of the diphtheria toxin. The methods have been tested on a sample of 36 clinical isolates. The possibility of significant detection of the toxigenic properties of the Corynebacterium strain, grown for 1 day, has been demonstrated. The developed methods allow for the detection of diphtheria toxin in concentrations of 3-4 ng/ml. The developed test systems are a perspective tool for diphtheria diagnostics because of significant time shortening as compared to traditional microbiological methods. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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