Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.
| Autor: | Beseda I; Inst. Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna 1060, Austria., Czollner L, Shah PS, Khunt R, Gaware R, Kosma P, Stanetty C, Del Ruiz-Ruiz MC, Amer H, Mereiter K, Da Cunha T, Odermatt A, Classen-Houben D, Jordis U |
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| Jazyk: | angličtina |
| Zdroj: | Bioorganic & medicinal chemistry [Bioorg Med Chem] 2010 Jan 01; Vol. 18 (1), pp. 433-54. Date of Electronic Publication: 2009 Oct 23. |
| DOI: | 10.1016/j.bmc.2009.10.036 |
| Abstrakt: | The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed. (Copyright (c) 2009 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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