Different contributions of side-chains in beta-D-(1-->3,6)-galactans on intestinal Peyer's patch-immunomodulation by polysaccharides from Astragalus mongholics Bunge.

3,6)-galactans on intestinal Peyer's patch-immunomodulation by polysaccharides from Astragalus mongholics Bunge. -->
Autoři: Kiyohara H; Department of Drug Discovery Science, Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Uchida T, Takakiwa M, Matsuzaki T, Hada N, Takeda T, Shibata T, Yamada H
Zdroj: Phytochemistry [Phytochemistry] 2010 Feb; Vol. 71 (2-3), pp. 280-93. Date of Electronic Publication: 2009 Nov 13.
Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't
Jazyk: English
Informace o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE
Imprint Name(s): Publication: 2003- : London : Elsevier
Original Publication: 1961-2003: Oxford : Pergamon Press.
Výrazy ze slovníku MeSH: Astragalus Plant/*chemistry , Galactans/*pharmacology , Immunologic Factors/*pharmacology , Pectins/*pharmacology , Peyer's Patches/*drug effects , Plant Extracts/*pharmacology, Galactans/chemistry ; Galactans/isolation & purification ; Immunologic Factors/chemistry ; Immunologic Factors/isolation & purification ; Molecular Structure ; Pectins/chemistry ; Pectins/isolation & purification ; Peyer's Patches/immunology ; Plant Components, Aerial ; Plant Extracts/chemistry
Abstrakt: Thirteen polysaccharides isolated from an extract of the aerial portions of Astragalus mongholics Bunge demonstrated immunomodulating activity against Peyer's patch immunocompetent cells. Nine of the active polysaccharide fractions were composed of either arabinogalactans, pectic arabinogalactans or pectins. The activities of the arabinogalactans and pectic arabinogalactans were associated with beta-D-(1-->3)-galactan moieties branched with beta-D-(1-->6)-galactooligosaccharide side-chains having degrees of polymerization of 8 or less. Degradation of the beta-D-(1-->3)-galactan or beta-D-(1-->6)-galactosyl side-chains in the arabinogalactans significantly decreased immunomodulating activity. Rhamnogalacturonan I (RG-I) with beta-D-(1-->3,6)-galactosyl side-chains having terminal beta-D-GlcA showed activity in the pectin-enriched fractions. Interestingly, the terminal GlcA was not required for activity of the arabinogalactan-enriched fractions, suggesting at least two different immunomodulating structures.
(2009 Elsevier Ltd. All rights reserved.)
Substance Nomenclature: 0 (Galactans)
0 (Immunologic Factors)
0 (Plant Extracts)
89NA02M4RX (Pectins)
Entry Date(s): Date Created: 20091117 Date Completed: 20100810 Latest Revision: 20181201
Update Code: 20221213
DOI: 10.1016/j.phytochem.2009.10.001
PMID: 19913859
Autor: Kiyohara H; Department of Drug Discovery Science, Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan., Uchida T, Takakiwa M, Matsuzaki T, Hada N, Takeda T, Shibata T, Yamada H
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2010 Feb; Vol. 71 (2-3), pp. 280-93. Date of Electronic Publication: 2009 Nov 13.
DOI: 10.1016/j.phytochem.2009.10.001
Abstrakt: Thirteen polysaccharides isolated from an extract of the aerial portions of Astragalus mongholics Bunge demonstrated immunomodulating activity against Peyer's patch immunocompetent cells. Nine of the active polysaccharide fractions were composed of either arabinogalactans, pectic arabinogalactans or pectins. The activities of the arabinogalactans and pectic arabinogalactans were associated with beta-D-(1-->3)-galactan moieties branched with beta-D-(1-->6)-galactooligosaccharide side-chains having degrees of polymerization of 8 or less. Degradation of the beta-D-(1-->3)-galactan or beta-D-(1-->6)-galactosyl side-chains in the arabinogalactans significantly decreased immunomodulating activity. Rhamnogalacturonan I (RG-I) with beta-D-(1-->3,6)-galactosyl side-chains having terminal beta-D-GlcA showed activity in the pectin-enriched fractions. Interestingly, the terminal GlcA was not required for activity of the arabinogalactan-enriched fractions, suggesting at least two different immunomodulating structures.
(2009 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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