| Autor: |
de Almeida AC; Center for Investigation in Pediatrics and Department of Pharmacology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Barbosa SM, Barjas-Castro Mde L, Olalla-Saad ST, Condino-Neto A |
| Jazyk: |
angličtina |
| Zdroj: |
Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2009; Vol. 31 (4), pp. 636-40. |
| DOI: |
10.3109/08923970902939256 |
| Abstrakt: |
The aim of this work was to evaluate the regulation of SIRP alpha, an inhibitory phagocyte receptor, and the phosphatase SHP-1 in monocytes of patients with autoimmune hemolytic anemia, and the role of dexamethasone on SIRP alpha and SHP-1 gene expression and erythrophagocytosis in vitro. SIRP alpha and SHP-1 expression was higher in monocytes from AIHA patients compared with normal, returning to normal after glucocorticoid therapy. SIRP alpha and SHP-1 mRNA expression was upregulated in healthy monocytes treated with dexamethasone compared with basal; however, the erythrophagocytic ability was not altered. Our results point to a minor role of SIRP alpha and SHP-1 in determining AIHA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
