| Autor: |
Mayer MM; Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York., Osler AG, Bier OG, Heidelberger M |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of experimental medicine [J Exp Med] 1946 Nov 30; Vol. 84 (6), pp. 535-48. |
| DOI: |
10.1084/jem.84.6.535 |
| Abstrakt: |
1. The evidence presented indicates that Mg(++), or other cation such as Ca(++), Ni(++), or Co(++), is essential for the hemolytic action of C'. Ca(++), Ni(++), and Co(++) are less effective than Mg(++). The hemolytic system usually does not contain sufficient Mg(++) for optimal hemolytic activity so that a marked enhancement can be obtained by addition of extra Mg(++). 2. The enhancing action of tissue fluids can be ascribed to their contribution of Mg(++). 3. Substances which bind Mg(++) and Ca(++) are anticomplementary when added to the usual hemolytic system which contains only a small quantity of Mg(++). This type of anticomplementary effect can be overcome by addition of extra Mg(++). 4. Ca(++) may also be essential to the lytic process but its action is much less pronounced than that of Mg(++). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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