Niemann-Pick disease, type B with TRAP-positive storage cells and secondary sea blue histiocytosis.

Autor: Sharma P; Haematology Department, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. prashant.sh@gmail.com, Kar R, Dutta S, Pati HP, Saxena R
Jazyk: angličtina
Zdroj: European journal of histochemistry : EJH [Eur J Histochem] 2009 Sep 23; Vol. 53 (3), pp. e22. Date of Electronic Publication: 2009 Sep 23.
DOI: 10.4081/ejh.2009.e22
Abstrakt: We present 2 cases of Niemann Pick disease, type B with secondary sea-blue histiocytosis. Strikingly, in both cases the Pick cells were positive for tartrate resistant acid phosphatase, a finding hitherto described only in Gaucher cells. This report highlights the importance of this finding as a potential cytochemical diagnostic pitfall in the diagnosis of Niemann Pick disease.
Databáze: MEDLINE