| Autor: |
de Laat PC; Department of Pediatrics, University Hospital Nijmegen, The Netherlands., Weemaes CM, Bakkeren JA, van den Brandt FC, van Lith TG, de Graaf R, van Munster PJ, Stoelinga GB |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical immunology and immunopathology [Clin Immunol Immunopathol] 1991 Jan; Vol. 58 (1), pp. 92-101. |
| DOI: |
10.1016/0090-1229(91)90151-y |
| Abstrakt: |
Two families were investigated in which the mothers had selective IgA deficiency and circulating class-specific anti-IgA antibodies. Both gave birth to two children who were found to be IgA deficient. Three of these children developed anti-IgA antibodies before puberty. In vitro immunoglobulin production studies performed in the children of both families revealed an IgA B cell defect combined with IgA-specific excessive T suppressor function in all four. The mechanisms by which transplacental passage of maternal anti-IgA antibodies could have interfered with the developing IgA system in the offspring are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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