| Autor: |
Wong RC; Department of Cardiovascular Medicine/F15, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA, rwongcc@gmail.com., Dumont CA, Austin BA, Kwon DH, Flamm SD, Thomas JD, Starling RC, Desai MY |
| Jazyk: |
angličtina |
| Zdroj: |
The international journal of cardiovascular imaging [Int J Cardiovasc Imaging] 2010 Feb; Vol. 26 (2), pp. 151-9. Date of Electronic Publication: 2009 Oct 13. |
| DOI: |
10.1007/s10554-009-9516-4 |
| Abstrakt: |
The purpose of this study was to examine the relationship between noninvasive measurements of ventricular-vascular coupling (VVC) with exercise tolerance, and compared the value of VVC versus other traditional determinants of exercise capacity in this population. 43 patients with ischemic CMP (age 59 +/- 9 years, mean EF 24 +/- 8%) underwent cardiopulmonary exercise testing, echocardiography and cardiac magnetic resonance (CMR). VVC was defined non-invasively by the ratio of ventricular systolic elastance (Ees) to the arterial elastance (Ea), where Ees = end-systolic pressure/end-systolic volume index and Ea = end-systolic pressure/stroke volume index. VVC significantly correlated with baseline heart rate (HR), peak exercise systolic blood pressure, maximum oxygen consumption (MVO(2)) and peak O(2) pulse (MVO(2)/HR). A higher VVC was associated with higher LVEF and RVEF but showed inverse relation to mitral E wave velocity. Univariate predictors of MVO(2) are baseline HR, chronotropic reserve, VVC and aortic distensibility; whilst mitral E wave velocity, LVEF, VVC, Ees significantly correlated with peak O(2) pulse. By stepwise multivariate analysis, VVC remained the only independent predictor of peak O(2) pulse. Ventricular-vascular coupling at rest may be a clinically important parameter in predicting exercise capacity in patients with advanced heart failure, and may become an additional target for therapeutic interventions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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