Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis.

Autor: Mai NT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Tuan TV, Wolbers M, Hoang DM, Nga TV, Chau TT, Chuong LV, Sinh DX, Nghia HD, Phong ND, Phu NH, Diep TS, Hang HT, Chau Nv, Farrar J, Schultsz C, Hien TT, Simmons CP
Jazyk: angličtina
Zdroj: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2009 Nov 01; Vol. 49 (9), pp. 1387-92.
DOI: 10.1086/630207
Abstrakt: Adjunctive treatment to improve outcome from bacterial meningitis has centered on dexamethasone. Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF:plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo.
Databáze: MEDLINE