Ethinyl estradiol/drospirenone for the treatment of the emotional and physical symptoms of premenstrual dysphoric disorder.

Autor: Rapkin AJ; David Geffen School of Medicine at UCLA, Department of Obstetrics & Gynecology, 10833 Le Conte Avenue, Los Angeles, CA 90095-1740, USA. arapkin@mednet.ucla.edu., McDonald M, Winer SA
Jazyk: angličtina
Zdroj: Women's health (London, England) [Womens Health (Lond)] 2007 Jul; Vol. 3 (4), pp. 395-408.
DOI: 10.2217/17455057.3.4.395
Abstrakt: A combined oral contraceptive pill containing 20 microg of ethinyl estradiol and 3 mg of the progestin drospirenone in a novel dose regimen (24 active pills followed by 4 placebo pills), has demonstrated efficacy for the symptoms of premenstrual dysphoric disorder, a severe form of premenstrual syndrome, with an emphasis on the affective symptoms. Drospirenone has progestagenic, anti-androgenic and anti-aldosterone properties, which differ from earlier generations of progestins, and reducing the hormone pill-free interval allows for better suppression of ovarian steroid production.
Databáze: MEDLINE