| Autor: |
Lipina TV, Vishnivetskaia GB |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova [Zh Vyssh Nerv Deiat Im I P Pavlova] 2009 Jul-Aug; Vol. 59 (4), pp. 482-7. |
| Abstrakt: |
This study was aimed to determine the effect of D2/D3 receptor antagonist sulpiride on the expression of immobility reflex ("pinch-test") and pinch-induced catalepsy ("bar-test") of CBA/Lac male mice depending on their social status ("aggressors" with repeated experience of victories or a "losers" with repeated experience of social defeats). Sulpiride (20 mg/kg, i.p.) was acutely administered to "aggressors" and "losers" after 10 and 20 daily social contacts (victories or social defeats) and to a control group of male mice. Repeated experience of social victories and defeats altered the immobility duration in both tests and modified the expression of the sulpiride effect. In the pinch-tets, the duration of immobility was longer in "loosers" than in "aggressors". In the bar-test, the pinch-induced catalepsy was more expressed in "losers" and "aggressors" as compared to control. Sulpiride was more effective in increasing immobility of"aggressors" and had a weaker effect on the control and "losers". Therefore, the effect of sulpiride is affected by the social status of the animals. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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