Prevalence of extensively drug-resistant tuberculosis in Vladimir and Orel regions, Russia.

Autor:	Punga VV; Central TB Research Institute of Russian Academy of Medical Sciences, Moscow, Russian Federation., Jakubowiak WM, Danilova ID, Somova TR, Volchenkov GV, Kazionnyy BY, Nemtsova ES, Kiryanova EV, Kourbatova EV
Jazyk:	angličtina
Zdroj:	The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2009 Oct; Vol. 13 (10), pp. 1309-12.
Abstrakt:	Setting: Joint World Health Organization (WHO) projects in Vladimir and Orel regions, Russia. Objective: To study the prevalence of extensively drug-resistant (XDR) tuberculosis (TB). Methods: Drug susceptibility testing of second-line drugs (ofloxacin, kanamycin, capreomycin, ethionamide, cycloserine and para-aminosalicylic acid) was performed on isolates from multidrug-resistant TB cases from 1 January to 31 December 2006. Results: In Orel, 16 (21.3%) of 75 tested isolates were XDR-TB; in Vladimir, 9 (4.9%) of 182 isolates were XDR-TB. Bilateral lung involvement was significantly associated with XDR-TB (prevalence ratio = 2.61, 95%CI 1.01-6.72). Conclusion: XDR-TB has emerged in Russia. It is crucial to prevent, diagnose and treat TB and MDR-TB more effectively.
Databáze:	MEDLINE
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