| Autor: |
Vieira GM Jr; Institute of Chemistry, Nuclei of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, Araraquara, SP, Brazil, CP 355, CEP 14801-97., Gonçalves Tde O, Regasini LO, Ferreira PM, Pessoa Cdo O, Costa Lotufo LV, Torres RB, Boralle N, Bolzani Vda S, Cavalheiro AJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2009 Oct; Vol. 72 (10), pp. 1847-50. |
| DOI: |
10.1021/np9004079 |
| Abstrakt: |
A crude bioactive EtOH extract of the twigs of Casearia obliqua afforded two new clerodane diterpenes, caseobliquins A (1) and B (2). Additionally, bioactivity-directed fractionation on a bioactive hexane extract of the leaves from this species led to the isolation of the known clerodane diterpenes rel-6beta-hydroxyzuelanin-2beta-benzoate and rel-2alpha-hydroxyzuelanin-6beta-benzoate (3 and 4) as a mixture and 2beta-hydroxyzuelanin-6beta-cinnamate (5). The structures of the new clerodanes 1 and 2 were established on the basis of their 1D and 2D NMR spectroscopic data, and the new compound 1 and the known substance 5 had their absolute configurations determined by circular dichroism spectroscopy. The cytotoxicity of several of the compounds isolated was evaluated against a small panel of human tumor cell lines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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