Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15 ppm formaldehyde vapor.

Autor: Kuper CF; Department of Toxicology and Applied Pharmacology, TNO Quality of Life, 3704HE Zeist, The Netherlands. frieke.kuper@tno.nl, van Oostrum L, Ma-Hock L, Durrer S, Woutersen RA
Jazyk: angličtina
Zdroj: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie [Exp Toxicol Pathol] 2011 Jan; Vol. 63 (1-2), pp. 25-32. Date of Electronic Publication: 2009 Sep 26.
DOI: 10.1016/j.etp.2009.09.004
Abstrakt: To investigate if local lymphoid tissues are a target of FA, nasopharynx-associated lymphoid tissues (NALT) and upper-respiratory tract-draining lymph nodes were examined in a 28-day inhalation study with FA vapor in Fischer-344 rats and B6C3F1 mice. Paraffin-embedded tissues were sectioned and stained with H&E or stained immunohistochemically for cell proliferation (BrdU incorporation). Light microscopy revealed simple hyperplasia of NALT lymphoepithelium of rats exposed to 15 ppm and an increased proliferation rate of the epithelial cells. Principal component (discriminant) analysis of rat NALT and lymph nodes data did not reveal other effects or effects at lower exposure levels. Mice tissues were not affected. It was concluded that hyperplasia of the lymphoepithelium of NALT of rats exposed to 15 ppm was the only distinct effect of FA vapor on local lymphoid tissues (NALT and lymph nodes) of Fischer-344 rats and B3C3F1 mice.
(Copyright © 2009 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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