[Flavonoids from Diospyros kaki inhibit the adhesion between lymphocyte and dorsal root ganglion].

Autor:	Bei WJ; Guangzhou Pharmaceutical University, The Institute of Chinese Medicinal Sciences, Guangzhou 510006, China. bei-wj2000@yahoo.com.cn, Xu AL, Li CY, Cabot PJ, Hermanussen S
Jazyk:	čínština
Zdroj:	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials [Zhong Yao Cai] 2009 May; Vol. 32 (5), pp. 740-4.
Abstrakt:	Objective: To investigate the effects of flavonoids from the leaves of Diospyros kaki L (FLDK) on the adhesion between the lymphocyte and the neurone. Methods: Centrifugal assay for fluorescence-bsaed cell adhesion was used to assay the adhesion between the lymphocyte and the dorsal root ganglion (DRG). Results: The adhesion was significantly suppressed in the presence of FLDK dose-dependently at 5, 25 microg/mL concentration. FLDK was also effective to inhibit the adhesion under the challenge of ICAM-1 by 28.5% and 50.1%, respectively. Furthermore, FLDK enforced the inhibition of anti-NCAM antibody on the lymphocyte adhesion to DRG cells. Conclusion: FLDK might contribute to the prevention and treatment of the inflammation injury under neuron insult such as ischemia/reperfusion, neurotrauma and other neurodegenerative disease by inhibiting the adhesion between lymphocytes and neurons.
Databáze:	MEDLINE
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