Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.

Autor: Pasternak A; Merck Research Laboratories, Rahway, NJ 07065, USA. alexander_pasternak@merck.com, Goble SD, deJesus RK, Hreniuk DL, Chung CC, Tota MR, Mazur P, Feighner SD, Howard AD, Mills SG, Yang L
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Nov 01; Vol. 19 (21), pp. 6237-40. Date of Electronic Publication: 2009 Aug 26.
DOI: 10.1016/j.bmcl.2009.08.076
Abstrakt: This Letter describes optimization of ghrelin receptor antagonists and inverse agonists starting from a screening hit.
Databáze: MEDLINE