| Autor: |
García-Hernández MH; Laboratorio de Inmunología y Biología Celular y Molecular, Facultad de Ciencias Químicas, UASLP, San Luis Potosi, SLP, México., Alvarado-Sánchez B, Calvo-Turrubiartes MZ, Salgado-Bustamante M, Rodríguez-Pinal CY, Gámez-López LR, González-Amaro R, Portales-Pérez DP |
| Jazyk: |
angličtina |
| Zdroj: |
Parasite immunology [Parasite Immunol] 2009 Oct; Vol. 31 (10), pp. 597-603. |
| DOI: |
10.1111/j.1365-3024.2009.01149.x |
| Abstrakt: |
Chronic intestinal parasite infection can induce both persistent immune activation and defective responsiveness of T cells. This study aimed to assess the number and function of T regulatory (Treg) cells in children with intestinal parasite infection. We have studied the peripheral blood from 93 children, 53 of them parasitized with protozoa, helminths, or both; the remainder were non parasitized, healthy controls. The number and function of CD4(+) CD25(high) and CD4(+) Foxp3(+) cells were similar in parasitized and control children. In contrast, there was a significant increase in the levels of CD3(+) CD69(+), CD4(+) CTLA-4(+), and CD8(+) CD28(-) T cells in helminth infected children. Moreover, some of these patients showed a diminished response to CD3/CD28 stimulation in comparison with the control children. Our data strongly suggest that whilst Treg cells are not affected by intestinal parasite infection, CD3(+) CD69(+), CD4(+) CTLA-4(+) and CD8(+) CD28(-) lymphocytes may play an important, but as yet undetermined role in the diminished immune competence observed in parasitized children. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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