Polyglutamine dances the conformational cha-cha-cha.

Autor: Miller J, Rutenber E, Muchowski PJ
Jazyk: angličtina
Zdroj: Structure (London, England : 1993) [Structure] 2009 Sep 09; Vol. 17 (9), pp. 1151-3.
DOI: 10.1016/j.str.2009.08.004
Abstrakt: While polyglutamine repeats appear in dozens of human proteins, high-resolution structural analysis of these repeats in their native context has eluded researchers. Kim et al. now describe multiple crystal structures and demonstrate that polyglutamine in huntingtin dances through multiple conformations.
Databáze: MEDLINE