| Autor: |
Ragheb A; Department of Medicine, Division of Nephrology, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada., Attia A, Eldin WS, Elbarbry F, Gazarin S, Shoker A |
| Jazyk: |
angličtina |
| Zdroj: |
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia [Saudi J Kidney Dis Transpl] 2009 Sep; Vol. 20 (5), pp. 741-52. |
| Abstrakt: |
Thymoquinone (TQ), 2-Isopropyl-5-methyl-1, 4-benzoquinone, is one of the most active ingredients of Nigella Sativa seeds. TQ has a variety of beneficial properties including anti-oxidative and anti-inflammatory activities. Studies have provided original observations on the role of oxidative stress and inflammation in the development of renal diseases such as glomerulonephritis and drug-induced nephrotoxicity. The renoprotective effects of TQ have been demonstrated in animal models. Also, TQ has been used successfully in treating allergic diseases in humans. The aim of this review is to highlight the importance of reactive oxygen species in renal pathophysiology and the intriguing possibility for a role of TQ in the prevention of and/or protection from renal injury in humans. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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