| Autor: |
Badowska-Szalewska E; Deaprtment of Anatomy and Neurobiology, Medical University of Gdańsk, Poland. ewabadowska@amg-gda.pl, Klejbor I, Sidor-Kaczmarek J, Cecot T, Lietzau G, Spodnik JH, Moryś J |
| Jazyk: |
angličtina |
| Zdroj: |
Folia morphologica [Folia Morphol (Warsz)] 2009 Aug; Vol. 68 (3), pp. 119-28. |
| Abstrakt: |
The aim of this study was to investigate the influence of two periods of life, namely P28 and P360, on the changes in interleukin-1beta (IL-1beta) immunoreactivity (-ir) in the hippocampus (CA1, CA3, DG) and amygdala (central-CeA, medial-MeA) caused by acute and repeated open field (OF), or by forced swim (FS) exposition. Rats were divided into groups: non-stressed, exposed to acute (one-time for 15 min) and chronic stressors (21 days for 15 min daily). We found IL-1beta-ir in the control group to be higher in P360 than in P28. In P28, under OF and FS exposure, IL-1beta-ir in the CeA remained unaltered but increased in the MeA and in the hippocampus after acute and chronic stress. In P360 no changes were observed in the IL-1beta-ir level after acute and chronic stimulation. These data demonstrate that only the levels of IL-1beta-ir in juvenile rat brains are affected by FS and OF. Additionally, there was no significant difference between FS and OF stimulation in IL-1beta-ir. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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