Production of autoantibodies to glutamate during Alzheimer's dementia.

Autor: Davydova TV; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, N. A. Alekseev Moscow Clinical Psychiatric Hospital No. 1, Moscow. dav-ta@yandex.ru, Voskresenskaya NI, Gorbatov VY, Fomina VG, Doronina OA, Maksunova IV
Jazyk: English; Russian
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2009 Apr; Vol. 147 (4), pp. 405-7.
DOI: 10.1007/s10517-009-0530-2
Abstrakt: Increased production of autoantibodies to glutamate was found in blood plasma from patients with Alzheimer's dementia. The content of autoantibodies to glutamate in patients with early-onset Alzheimer's disease was much lower than in those with late-onset Alzheimer's disease (1.40+/-0.07 and 1.80+/-0.07 arb. units, p<0.001). The level of autoantibodies to glutamate in patients with mixed - Alzheimer's disease was 1.60+/-0.01 arb. units.
Databáze: MEDLINE
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