| Autor: |
Mogni ME; Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, UK., Costa A, Ioannou C, Bell SD |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemistry [Biochemistry] 2009 Sep 22; Vol. 48 (37), pp. 8774-5. |
| DOI: |
10.1021/bi9012512 |
| Abstrakt: |
Recent work has identified a "glutamate switch" in six of the seven clades of AAA+ ATPases. The glutamate switch acts to transduce information regarding substrate binding to the ATPase active site. We provide biochemical evidence that a highly conserved threonine residue acts as a glutamate switch in the replicative helicase, MCM, and, thus, reveal that the glutamate switch is a feature common to all seven AAA+ clades. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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