| Autor: |
Milinkevich KA; Department of Chemistry, One Shields Ave., University of California, Davis, CA 95616, USA., Yoo CL, Sparks TC, Lorsbach BA, Kurth MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Oct 01; Vol. 19 (19), pp. 5796-8. Date of Electronic Publication: 2009 Aug 06. |
| DOI: |
10.1016/j.bmcl.2009.07.139 |
| Abstrakt: |
Acid hydrazides were coupled with acrylic acid derivatives and cyclodehydration gave 1,3,4-oxadiazoles. Lastly, in-situ nitrile oxide formation from aryl oximes treated with sodium hypochlorite, and subsequent 1,3-dipolar cycloaddition to the exomethylene moiety delivered 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles. This library was evaluated in a high-throughput screen at Dow AgroSciences. Several compounds were active against fungal pathogens and pest insects. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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