| Autor: |
Dosa PI; Arena Pharmaceuticals Inc., 6166 Nancy Ridge Drive, San Diego, CA 92121, United States. pidosa@umn.edu, Strah-Pleynet S, Jayakumar H, Casper M, Decaire M, Xiong Y, Lehmann J, Choi K, Elwell K, Wong A, Webb RR, Adams JW, Ramirez J, Richman JG, Thomsen W, Semple G, Teegarden BR |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Sep 15; Vol. 19 (18), pp. 5486-9. Date of Electronic Publication: 2009 Jul 18. |
| DOI: |
10.1016/j.bmcl.2009.07.073 |
| Abstrakt: |
Potent 5-HT(2A) inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective compounds that proved effective in modulating 5HT-induced amplification of ADP-stimulated human platelet aggregation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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