| Autor: |
Rambow-Larsen AA; University of Wisconsin, Department of Pathobiological Sciences, Madison, WI 53706, USA., Petersen EM, Gourley CR, Splitter GA |
| Jazyk: |
angličtina |
| Zdroj: |
Trends in microbiology [Trends Microbiol] 2009 Aug; Vol. 17 (8), pp. 371-7. Date of Electronic Publication: 2009 Aug 05. |
| DOI: |
10.1016/j.tim.2009.05.006 |
| Abstrakt: |
Brucella is an important zoonotic pathogen for which no human vaccine exists. In an infected host, Brucella resides in macrophages but must coordinate expression of multiple virulence factors for successful cell entry and trafficking to acquire this replicative niche. Brucella responds to environmental signals to regulate virulence strategies that circumvent or blunt the host immune response. The Brucella quorum sensing system is a nexus of control for several Brucella virulence factors including flagellar genes and the type IV secretion system. Other sensory transduction systems, such as BvrRS and the newly described LOV-HK, sense environmental factors to control virulence. Here, we examine the contributions of various regulatory systems to Brucella virulence. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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