| Autor: |
Andersen M; Department of Oncology, Rigshospitalet, Copenhagen, Denmark., Kristjansen PE, Hansen HH |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer treatment reviews [Cancer Treat Rev] 1990 Dec; Vol. 17 (4), pp. 427-36. |
| DOI: |
10.1016/0305-7372(90)90083-r |
| Abstrakt: |
The literature on second-line chemotherapy in small cell lung cancer (SCLC) for the period 1979-1989 is reviewed. The reports consisted mainly of Phase II type studies and comprised a total of 987 patients with relatively few patients per study. The information was frequently incomplete with regard to duration of response on first-line chemotherapy, length of any drug-free interval and duration of response on second-line chemotherapy. The overall second-line response rate was 30%, but only 5% were complete responses (CR). The response rates obtained by the combination of cisplatinum (P) and VP-16 (E) or reinduction therapy were 45% and 64% (medians), respectively. These rates were superior to regimens consisting of supposedly non-cross-resistant agents. With P and E not given in combination, the response rates were less than 20%. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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