Protective effect of Terminalia chebula against lysosomal enzyme alterations in isoproterenol-induced cardiac damage in rats.
| Autor: | Suchalatha S; Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India., Devi CS |
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| Jazyk: | angličtina |
| Zdroj: | Experimental and clinical cardiology [Exp Clin Cardiol] 2005 Summer; Vol. 10 (2), pp. 91-5. |
| Abstrakt: | Background: Terminalia chebula is an ayurvedic drug recommended for the treatment of heart diseases. Earlier studies by the authors validated the beneficial cardioprotective effect of T chebula against isoproterenol-induced myocardial infarction. Objectives: To evaluate the therapeutic efficacy of T chebula in protecting against isoproterenol-induced lysosomal membrane damage. Methods: Lysosomal enzyme activities from the serum, heart and lysosomal fractions were determined. The triphenyltetrazolium chloride assay was used to confirm the protective effect of T chebula on the myocardium. Results: Isoproterenol administration produced significant cardiac damage (as seen by the triphenyltetrazolium chloride assay) and significantly altered lysosomal enzyme activities. Pretreatment with an ethanol extract of T chebula was found to retain near normal activities of lysosomal enzymes in rats given T chebula or T chebula plus isoproterenol compared with rats given isoproterenol alone. Conclusions: Pretreatment with T chebula extract stabilizes the lysosomal membrane and, thus, may have prevented myocardial damage. |
| Databáze: | MEDLINE |
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