| Autor: |
Gamble JF; Biopharmaceutics R&D, Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, England., Tobyn M, Dennis AB, Shah T |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmaceutical development and technology [Pharm Dev Technol] 2009 Jul 22, pp. . Date of Electronic Publication: 2009 Jul 22. |
| DOI: |
10.1080/10837450903095342 |
| Abstrakt: |
This paper reports the use of an in-gap ribbon porosity calculation for the optimisation of roller compaction ribbon parameters in order to control downstream granule and tablet properties for a typical pharmaceutical formulation. The study demonstrates the effect of changes to roll speed and roll gap on the relative level of ribbon compaction for ribbons with equivalent in-gap porosities. It is demonstrated that in-gap ribbon porosity can be applied to enable optimization of the downstream granule processability characteristics for a typical pharmaceutical formulation and an understanding of the control space of a roller compaction process. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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