| Autor: |
Starokadomskiĭ PL, Dubeĭ IIa |
| Jazyk: |
ruština |
| Zdroj: |
Ukrains'kyi biokhimichnyi zhurnal (1999 ) [Ukr Biokhim Zh (1999)] 2005; Vol. 77 (6), pp. 79-85. |
| Abstrakt: |
The delivery of peptide drugs via the buccal mucosa is more convenient and safe approach than most other delivery methods. However, the efficiency of the buccal system of protein delivery is not yet able to compete with injection method. To improve its efficacy a new generation of absorption promoters that would be sufficiently enchance penetration and at the same time cause no irritation or unpleasant taste should be developed. Lysalbinic acid, a product of the alkaline hydrolysis of egg albumin, meets those requirements. The paper describes production and general physico-chemical properties of the lysalbinic acid. Lysalbinic acid has been shown to increase permeability of the oral mucosa for some peptide compounds. It is recommended to use lysalbinic acid as an absorption enhancer for the development of novel buccal peptide drugs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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