| Autor: |
Hutchinson CR; School of Pharmacy, University of Wisconsin, Madison 53706., Borell CW, Donovan MJ, Kato F, Motamedi H, Nakayama H, Rubin RL, Streicher SL, Summers RG, Wendt-Pienkowski E, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Planta medica [Planta Med] 1991 Oct; Vol. 57 (7), pp. S36-43. |
| Abstrakt: |
The possibilities for the design of new drug screening and development strategies directed to a specific objective on the basis of genetic engineering of microorganisms is discussed from two points of view. Firstly, results of work on genetic hybrids of Streptomyces species for the production of new metabolites such as mederrhodin (1) and aloespanoarin II (4) are described. Secondly, the enhanced production of known metabolites such as tetracenomycin A2 (11) and tetracenomycin C (9) by recombinant Streptomyces species is considered. Mechanistic aspects of polyketide metabolism are included. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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