Clinical outcome of breast cancer occurring after treatment for Hodgkin's lymphoma: case-control analysis.
| Autor: | Alm El-Din MA; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. almeldin@gmail.com, Hughes KS, Raad RA, Goldberg SI, Aisenberg AC, Niemierko A, Taghian AG |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Radiation oncology (London, England) [Radiat Oncol] 2009 Jun 30; Vol. 4, pp. 19. Date of Electronic Publication: 2009 Jun 30. |
| DOI: | 10.1186/1748-717X-4-19 |
| Abstrakt: | Background: To evaluate diagnosis, management and outcome of breast cancer (BC) occurring after irradiation for Hodgkin's lymphoma (HL). Methods: 39 cases of BC in 28 HL survivors were retrospectively reviewed. 21 patients were included in a case-control analysis. Results: The median age at diagnosis of HL and BC was 25.3 and 45.3 years, respectively. The median interval to develop BC was 16.1 years. Eleven women (39.2%) had bilateral disease. Mode of detection of the index breast cancers was by mammographic screening in 17 patients (60.7%), palpable lump in 8 patients (28.6%), clinical examination in two patients (7.1%), and unknown in one patient (3.6%). Case-control analysis showed that histological features and prognosis of BC after HL were similar to those of primary BC, however, for BC after HL, mastectomy was the predominant surgery (P = .001) and adjuvant radiotherapy and anthracycline-based chemotherapy were less frequently used as compared to primary BC (P < .001 and .003, respectively). Conclusion: The previous history of HL does not appear to be a poor prognostic factor for BC occurring thereafter. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|