| Autor: |
Oldfield NJ; Molecular Bacteriology and Immunology Group, Institute of Infection, Immunity & Inflammation, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom., Worrall KE, Rycroft AN, Ali T, Wooldridge KG, Ala'Aldeen DA |
| Jazyk: |
angličtina |
| Zdroj: |
Vaccine [Vaccine] 2009 Aug 20; Vol. 27 (38), pp. 5278-83. Date of Electronic Publication: 2009 Jun 27. |
| DOI: |
10.1016/j.vaccine.2009.06.047 |
| Abstrakt: |
Actinobacillus pleuropneumoniae is a major respiratory pathogen of pigs; current vaccines provide only limited protection. AasP, a subtilisin-like serine protease, is a conserved outer membrane-localised autotransporter protein. We hypothesized that AasP would induce protective immunity and may thus constitute a useful component of a vaccine against A. pleuropneumoniae infection. Here we confirm experimentally that AasP is an antigenic in vivo-expressed protein. In pig protection studies, a detectable specific antibody response was induced in response to recombinant AasP. However, the vaccine was not capable of protecting pigs from colonization, infection or severe clinical disease resulting from challenge with the homologous A. pleuropneumoniae strain. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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