| Autor: |
Bornet EP, Entman ML, Van Winkle WB, Schwartz A, Lehotay DC, Levey GS |
| Jazyk: |
angličtina |
| Zdroj: |
Biochimica et biophysica acta [Biochim Biophys Acta] 1977 Jul 14; Vol. 468 (2), pp. 188-93. |
| DOI: |
10.1016/0005-2736(77)90113-4 |
| Abstrakt: |
The role of cyclic 3',5'-AMP in modulating sarcoplasmic reticulum from fast skeletal muscle was studied. The rate of Ca2+ uptake was stimulated in the presence of protein kinase plus 1 micron cyclic AMP. The stimulation was absent when denatured protein kinase was used. When an adenylate cyclase inhibitor was added, the uptake rates fell to 55% of control. This decrease in rate was partially overcome by 1 micron cyclic AMP. A modulating role for cyclic AMP in fast skeletal muscle is proposed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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