| Autor: |
Ayele W; Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia., Assefa T, Lulseged S, Tegbaru B, Berhanu H, Tamene W, Ahmedin Z, Tensai BW, Tafesse M, Goudsmit J, Berkhout B, Paxton WA, Debaar MP, Messele T, Pollakis G |
| Jazyk: |
angličtina |
| Zdroj: |
The open AIDS journal [Open AIDS J] 2009 May 20; Vol. 3, pp. 19-23. Date of Electronic Publication: 2009 May 20. |
| DOI: |
10.2174/1874613600903010019 |
| Abstrakt: |
In the absence of chemoprophylaxis, HIV-1 transmission occurs in 13-42% of infants born to HIV-1 positive mothers. All exposed infants acquire maternal HIV-1 antibodies that persist for up to 15 months, thereby hampering diagnosis. In resource limited settings, clinical symptoms are the indices of established infection against validated laboratory-based markers. Here we enrolled 1200 children hospitalized for diarrheal and other illnesses. 20-25% of those tested, aged 15 months or younger, were found to be HIV-1-seropositive. Where sufficient plasma was available, HIV-1 RNA detection was performed using a subtype-insensitive assay, with 71.1% of seropositive infants presenting with diarrhea showing positive. From sub-typing analysis, we identified that viruses of the C' sub-cluster were predominated amongst infants. Although this study may overestimate the HIV-1 frequency through testing symptomatic infants, diarrhea can be seen as a useful marker indicating HIV-1 infection in infants less than 15 months old. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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