| Autor: |
Lima RE; Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, Brazil. rhannalima@gmail.com, De Bortoli Cassiani SH |
| Jazyk: |
angličtina |
| Zdroj: |
Revista latino-americana de enfermagem [Rev Lat Am Enfermagem] 2009 Mar-Apr; Vol. 17 (2), pp. 222-7. |
| DOI: |
10.1590/s0104-11692009000200013 |
| Abstrakt: |
This study assessed potential drugs interactions in intensive care patients at a university hospital in Ceará, northeast Brazil. Of 102 patients studied, 72.5% were exposed to 311 potential drug-drug interactions; 64% of them were females aged 60 years or more and hospital stay was at least 9 days. A statistically significant association was found between number of drugs used and the occurrence of drug interactions. A total of 1,140 drugs were scheduled to be administered concomitantly; of these, 74% had potential for drug interactions. As for the classification of these events, 48.2% had a pharmacokinetic profile; 55.4% were of slow onset; 54.7% had moderate severity; and 60.6% were well-documented in the literature. The most common clinical action taken was 'to monitor signs and symptoms'. Nursing staff can perform 80% of preventive actions to avoid undesirable effects of drug interactions. However, nurses need to have adequate knowledge about drug action mechanisms and triggering factors associated to drug interactions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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