| Autor: |
da Silva Filho AA; Laboratório de Produtos Naturais, Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Av. Dr. Armando Sales de Oliveira, 201, CEP 14404-600, Franca, SP, Brazil. silvafilhoaa@yahoo.com.br, Resende DO, Fukui MJ, Santos FF, Pauletti PM, Cunha WR, Silva ML, Gregório LE, Bastos JK, Nanayakkara NP |
| Jazyk: |
angličtina |
| Zdroj: |
Fitoterapia [Fitoterapia] 2009 Dec; Vol. 80 (8), pp. 478-82. Date of Electronic Publication: 2009 Jun 18. |
| DOI: |
10.1016/j.fitote.2009.06.007 |
| Abstrakt: |
Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani, with an IC(50) value of 45 microg/mL, while GPE presented an IC(50) value of 49 microg/mL. Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC(50) values of 3.7 microg/mL and 7.0 microg/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC(50) values (about 20 microg/mL), while Hautriwaic acid lactone led to an IC(50) value of 0.8 microg/mL (D6 clone). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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