[N-terminal fragment of the brain natriuretic peptide and proinflammatory cytokines in patients with ischemic heart disease].

Autor:	Shalaev SV, Volkova SIu
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2009; Vol. 81 (5), pp. 30-6.
Abstrakt:	Aim: To determine plasmic concentrations of NT-proBNP, TNFalpha and IL-6 in patients with coronary heart disease (CHD) complicated with chronic cardiac failure (CCF); to compare these parameters with hemodynamic and functional ones. Material and Methods: A total of 157 CHD patients (84.1% males, mean age 54.3 +/- 6.8 years) were divided into 3 groups matched by sex and age according to the presence of CCF and left ventricular (LV) or systolic dysfunction. Results: CCF patients with LV dysfunction or intact LV function had much higher plasmic concentrations of neurohumoral mediators than CHD patients without CCF. A plasmic NT-proBNP level over 1000 fmol/ml was associated with a 5.5-fold increase in the relative risk of LV diastolic dysfunction for CCF patients (rR 5.6; 95% CI 1.4-30.0; p = 0.0065) while an IL-6 level over 6.1 pg/ml was associated with a 9-fold increase in this risk (rR 8.9; 95% CI 2.3-35.4; p = 0.00001). Plasmic NT-proBNP and IL-6 levels went up in correlation with a CCF functional class. A plasmic level of TNFalpha correlated with anginal functional class. Conclusion: Changes in plasmic levels of the above neuromediators are associated with changes in some LV function and functional parameters of CCF patients.
Databáze:	MEDLINE
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