| Autor: |
Hamilton JA; University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia., Leizer T, Piccoli DS, Royston KM, Butler DM, Croatto M |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1991 Oct 31; Vol. 180 (2), pp. 652-9. |
| DOI: |
10.1016/s0006-291x(05)81115-5 |
| Abstrakt: |
Cytokine regulation of synovial cell function has been considered to be involved in the pathogenesis of rheumatoid arthritis. Synoviocyte urokinase-type plasminogen activator (u-PA) expression may be relevant to the tissue remodelling, as well as to the cell migration and transformation occurring in rheumatoid joints. We report here that purified recombinant human oncostatin M (greater than or equal to approximately 0.2 U/ml = 1 pM) stimulated within six hr the u-PA activity of non-rheumatoid synovial fibroblast-like cells and raised their u-PA mRNA levels. Oncostatin M could augment PGE2 production and DNA synthesis in these cells; however, the increase in PGE2 was small compared with that caused by IL-1. Since oncostatin M is produced by immune cells, it may have a role in immune and inflammatory reactions by interacting with fibroblast populations, such as synoviocytes, in the manner described. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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