Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis.

Autor: Offen WA; Department of Chemistry, The University of York, Heslington, UK., Zechel DL, Withers SG, Gilbert HJ, Davies GJ
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2009 May 14 (18), pp. 2484-6. Date of Electronic Publication: 2009 Apr 06.
DOI: 10.1039/b902240f
Abstrakt: The Michaelis complex of the beta-mannosidase Man2A shows distortion to a (1)S(5) conformation adding to the growing body of evidence supporting catalysis through a boat conformation.
Databáze: MEDLINE