| Autor: |
Petit-Demoulière B; EA 3256 Neurobiologie de l'anxiété et de la dépression, Faculté de Médecine, BP 53508, 1 Rue Gaston Veil, F44035, Nantes Cedex 01, France., Massé F, Cogrel N, Hascoët M, Bourin M |
| Jazyk: |
angličtina |
| Zdroj: |
Behavioural brain research [Behav Brain Res] 2009 Dec 01; Vol. 204 (1), pp. 200-5. Date of Electronic Publication: 2009 Jun 10. |
| DOI: |
10.1016/j.bbr.2009.06.006 |
| Abstrakt: |
Four-plate test-retest (FPT-R) is a useful tool to study aversive memory and abolishment of benzodiazepine effects in experienced mice to four-plate test (FPT), namely one-trial tolerance. In the present study, we have used local injections paradigm, in order to localize structures implied in anxiolytic-like effects of two drugs in naïve and experienced mice: a benzodiazepine, diazepam that is only active in naïve mice; and a 5-HT(2A/2C) agonist, DOI that exert its anxiolytic-like effect both in naïve and experienced mice. Periacqueductal grey substance, three sub-regions of hippocampus (CA1, CA2 and CA3) and two nuclei of amygdala (BLA and LA) have been studied. Local injections did not cause any modifications of ambulatory activity. DOI injections elicit anxiolytic-like effects only when injected into CA2, in naïve and experienced mice. Diazepam had an anxiolytic-like effect in naïve mice, only when injected into lateral nucleus of amygdala; and in experienced mice when injected into PAG. These results help us to better understand the way of action of these two compounds and the structures functionally involved in their effects and in one-trial tolerance (OTT). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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