| Autor: |
Azizova OA; Laboratory of Biophysical Bases of Pathology, Institute of Physico-Chemical Medicine, Federal Agency for Public Health and Social Development, Moscow, Russia. o.azizova@mail.ru, Piryazev AP, Aseychev AV, Shvachko AG |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2009 Feb; Vol. 147 (2), pp. 201-3. |
| DOI: |
10.1007/s10517-009-0474-6 |
| Abstrakt: |
Changes in the capacity of fibrinogen subjected to oxidative modification to transform into fibrin under the effect of thrombin and to form a fibrin clot were studied. The effects of oxidized fibrinogen preparations on the clot formation by citrate-treated donor plasma were evaluated by the thrombin time test. Oxidation impaired the capacity of isolated fibrinogen to form a fibrin clot under the effect of thrombin. Addition of oxidized fibrinogen solutions to donor plasma led to prolongation of the plasma clotting time. Maximum addition (33% volume) of oxidized fibrinogen led to a 10-26% prolongation of clotting time in comparison with addition of the same volume of the same solution without fibrinogen. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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