Investigation of changes in NO content during long-term sensitization in edible snail using EPR-spectroscopy: effects of antibodies to calcium-binding protein S-100.

Autor: Gainutdinov KhL; E. K. Zavoiskii Kazan' Physicotechnical Institute, Russian Academy of Sciences, Novosibirsk, Russia. gainutdinov@mail.knc.ru, Andrianov VV, Gainutdinova TKh, Muranova LN, Obynochny AA, Timoshenko AKh, Shtark MB, Epstein OI, Yurtaeva SV, Jafarova GG
Jazyk: English; Russian
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2008 Dec; Vol. 146 (6), pp. 675-9.
DOI: 10.1007/s10517-009-0367-8
Abstrakt: EPR-spectroscopy experiments (electron paramagnetic resonance) demonstrated a decrease in NO production in the nervous system and heart of edible snail Helix lucorum after formation of long-term sensitization, a neurobiological model of anxiety and depression. The protective effect of antibodies to Ca(2+)-binding protein S-100 in dilution of 10(-12) on the formation of long-term sensitization was accompanied by partial recovery of NO synthesis in the nervous system and heart. These findings indicate that the imbalance in Ca(2+)-binding protein S-100 can lead to inhibition or modulation of some processes during plastic reorganization in the body and especially during pathological processes.
Databáze: MEDLINE
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