| Autor: |
Dinh T; Microcirculation Laboratory and Joslin-Beth Israel Deaconess Foot Center, the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Doupis J, Lyons TE, Kuchibhotla S, Julliard W, Gnardellis C, Rosenblum BI, Wang X, Giurini JM, Greenman RL, Veves A |
| Jazyk: |
angličtina |
| Zdroj: |
Diabetes care [Diabetes Care] 2009 Aug; Vol. 32 (8), pp. 1521-4. Date of Electronic Publication: 2009 Jun 09. |
| DOI: |
10.2337/dc09-0536 |
| Abstrakt: |
OBJECTIVE To investigate changes in the foot muscle energy reserves in diabetic non-neuropathic and neuropathic patients. RESEARCH DESIGN AND METHODS We measured the phosphocreatinine (PCr)/inorganic phosphate (Pi) ratio, total (31)P concentration, and the lipid/water ratio in the muscles in the metatarsal head region using MRI spectroscopy in healthy control subjects and non-neuropathic and neuropathic diabetic patients. RESULTS The PCr/Pi ratio was higher in the control subjects (3.23 +/- 0.43) followed by the non-neuropathic group (2.61 +/- 0.36), whereas it was lowest in the neuropathic group (0.60 +/- 1.02) (P < 0.0001). There were no differences in total (31)P concentration and lipid/water ratio between the control and non-neuropathic groups, but both measurements were different in the neuropathic group (P < 0.0001). CONCLUSIONS Resting foot muscle energy reserves are affected before the development of peripheral diabetic neuropathy and are associated with the endothelial dysfunction and inflammation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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